Fast knockdown and actual insect death don't always go hand in hand, as many insects recover after the initial knockdown. For this reason, pyrethrums are mixed with a synergist such as piperonyl butoxide (PBO) to increase insect mortality. Pyrethrums are primarily effective as a contact poison. They affect the central nervous system of insects. Pyrethrum is nontoxic to most mammals, making it among the safest insecticides in use. In fact, it has more approved EPA (Environmental Protection Agency) uses than any other insecticide.

Most outdoor misting systems are used throughout the year, although the frequency and duration of the pesticide application is reduced in the cooler months.  During peak mosquito season, the clock will activate the nozzles for up to 90 seconds up to 5 times per day.  A good system designer will evaluate the prevailing winds, humidity, time of use for the target area, and a number of other parameters in order to set the clock and determine the frequency of application.  The Mosquito Control Association of America has established a checklist for designers to use in addition to the Mosquito Misting Design Institute that certifies the qualifications of the designer.

In addition to the timer application, many systems include a remote control that allows the user to initiate the application of the pesticide at anytime.  This allows the user to treat with additional frequency should the need arise or clear the area of mosquitoes immediately prior to outdoor activities planned in the target area. The effectiveness of these systems is highly dependent upon the skills and expertise of the designer.

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